Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > News > Nanotweezers Unlock Anticancer Drug Secrets

August 22nd, 2007

Nanotweezers Unlock Anticancer Drug Secrets

Abstract:
The annoying bulges of an overwound telephone cord that shorten its reach and limit a caller's motion help explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators led by Mary-Ann Bjornsti, Ph.D., at St. Jude Children's Research Hospital, and Nynke Dekker, Ph.D., at Delft Technology University.

Using nanoscale magnetic tweezers (nanotweezers), the researchers showed that a camptothecin drug called topotecan kills cancer cells by preventing an enzyme called DNA topoisomerase I from uncoiling double-stranded DNA in those cells. Instead, the DNA becomes locked in tight twists called supercoils, which bulge out from the side of the overwound DNA molecule much like the bulges in an overwound telephone cord. If these supercoils accumulate and persist while the cell is trying to separate the two strands of DNA to make exact copies of the chromosomes during cell division, the cells will die.

Source:
physorg.com

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

Discoveries

Two-dimensional semiconductor comes clean April 27th, 2015

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

Sensor Designed in Iran Able to Remove Formaldehyde Gas from Environment April 27th, 2015

Cacao Seed Extract Used in Production of Catalytic Nanoparticles April 27th, 2015

Announcements

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

The 16th Trends in Nanotechnology International Conference (TNT 2015) unveils 25 Keynote Speakers: Call for abstracts open April 27th, 2015

Graphenea celebrates fifth anniversary April 27th, 2015

Sensor Designed in Iran Able to Remove Formaldehyde Gas from Environment April 27th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project