Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > New nanotoxicology study delivers promising results

Abstract:
Findings by a team of researchers from Oak Ridge National Laboratory and the University of Tennessee bode well for using single-walled carbon nanohorns, a particular form of engineered carbon-based nanoparticles, for drug delivery and other commercial applications.

New nanotoxicology study delivers promising results

OAK RIDGE, TN | Posted on August 17th, 2007

In results to be published in the journal Nanotoxicology (http://www.nanotoxicology.net), a team led by Meng-Dawn Cheng of ORNL's Environmental Sciences Division reported no pulmonary toxicity issues for single-walled carbon nanohorns. These findings are contrary to numerous studies in rats involving single-walled carbon nanotubes that have different shapes and sizes than those of nanohorns.

"We think the difference could be due to the lack of metal contaminants in single-walled carbon nanohorns as compared to single-walled carbon nanotubes, although many factors could be the cause as well," said one of the co-authors, Brynn Voy of ORNL's Biosciences Division.

Nanohorns are short, horn-shaped tubular structures capped with a conical tip. Individual nanohorns tend to cluster and form a Dahlia, or star-like, structure between 50 nanometers and 100 nanometers in diameter with the tips of individual nanohorns projecting outward from the center in all directions.

Of particular relevance is the fact nanohorns can be produced through simple laser ablation of a pure carbon target without the use of transition metal catalysts. Researchers theorize that the metal contaminants might be the cause of inflammatory responses and oxidative stress reported in inhalation studies using single-walled carbon nanotubes.

"Our primary objective in this study was to characterize the pulmonary response of single-wall carbon nanohorns and compare our results to published data concerning single-wall carbon nanotubes," the authors wrote. They acknowledge that the two forms of nanostructures can be vastly different in eliciting biological responses so they took great care in making the comparison.

In addition to nanohorns' potential for drug delivery purposes, researchers believe they can be useful for hydrogen storage in energy and fuel cell applications. Authors of the paper believe carbon nanohorns could find large-scale applications sooner than carbon nanotubes because they are easier to produce and because of the likelihood that they do not pose a health hazard.

Other authors of the paper, Assessing the Pulmonary Toxicity of Single-Walled Carbon Nanohorns, are Rachel Lynch of ORNL's Biosciences Division, Dana Glass and Shannon Mahurin of the Environmental Sciences Division, and Arnold Saxton and Robert Donnell of the University of Tennessee. This research was funded through the ORNL Laboratory Directed Research and Development program.

UT-Battelle manages Oak Ridge National Laboratory for the Department of Energy.

####

For more information, please click here

Contacts:
Ron Walli
Communications and External Relations
865.576.0226

Copyright © Oak Ridge National Laboratory

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

Designing ultrasound tools with Lego-like proteins August 29th, 2016

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

Discoveries

Continuous roll-process technology for transferring and packaging flexible LSI August 29th, 2016

Meteorite impact on a nano scale August 29th, 2016

Designing ultrasound tools with Lego-like proteins August 29th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Announcements

Continuous roll-process technology for transferring and packaging flexible LSI August 29th, 2016

Meteorite impact on a nano scale August 29th, 2016

Designing ultrasound tools with Lego-like proteins August 29th, 2016

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Safety-Nanoparticles/Risk management

UK NANOSAFETY GROUP publishes 2nd Edition of guidance to support safe working with nanomaterials May 30th, 2016

PETA science group publishes a review on pulmonary effects of nanomaterials: Archives of Toxicology publishes a review of scientific studies on fibrotic potential of nanomaterials May 26th, 2016

Common nanoparticle has subtle effects on oxidative stress genes May 11th, 2016

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic