Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

android tablet pc

Home > Press > Military to study better pain relief in battle zones

University of Michigan scientists win $1.3M grant to create and test nanoparticles that may deliver morphine to wounded soldiers faster and more safely

Military to study better pain relief in battle zones

ANN ARBOR, MI | Posted on July 30th, 2007

University of Michigan scientists have received a pilot grant of nearly $1.3 million from the Defense Advanced Research Projects Agency to test whether nanoparticles can solve a pressing problem in battle zones like Iraq: how to administer sustained, safe doses of the most effective painkillers to injured soldiers, long before they can reach expert medical help.

The ultimate goal is to develop tiny drug-bearing particles that a fellow soldier "or perhaps the injured soldier himself" could inject with a pen-like device, even in the heat of combat. That would solve one of the challenges now. Morphine, an effective painkiller that the military commonly uses for the acute pain of battle injuries, currently needs to be injected by skilled medical personnel and has to be monitored carefully to control its troublesome tendency to suppress normal breathing.

"This proposal provides an approach to achieve sustained, safe pain control on the battlefield," says the U-M research team's leader, James R. Baker, Jr., M.D., director of the Michigan Nanotechnology Institute for Medicine and Biological Sciences.

"It uses different medicines coupled to polymers to release drugs and antidotes to provide adequate pain relief while avoiding complications. If successful, it could markedly improve the treatment of soldiers in the field," says Baker, the Ruth Dow Doan Professor of Internal Medicine in the U-M Medical School.

The work could have a broad impact. In the war in Iraq, more than 26,900 U.S. soldiers have been wounded in action as of late July. It's known that battlefield pain, if not relieved adequately, can lead to post-traumatic stress disorders.

A large multidisciplinary team of U-M scientists will use the grant to design multipurpose nanoparticles and test how well they perform several tasks under simulated physiological conditions in the laboratory. Ultimately, they want the particles to be able to:

* control the release of morphine over extended periods before a soldier can be evacuated to a military acute care facility,

* continuously monitor the soldier�s breathing and if needed, release a drug called Naloxone that is used to counter morphine�s effects on breathing.

The team, which includes synthetic, analytical and medicinal chemists, will expand on the use of dendrimer platforms, a technology previously developed at the U-M. They will design ultra-small polymer particles called dendrimers capable of carrying morphine and Naloxone into the body and releasing them in controlled amounts. They will develop sensors that the dendrimers will also carry to monitor a soldier's respiration and trigger Naloxone release, or halt it, as needed.

If the concept proves successful after the first year of in vitro studies, Baker and his team want to apply for continued DARPA funding to proceed with animal and eventually human studies.

Other U-M team members include Abraham F. L. Vanderspek, M.D., associate professor of anesthesiology; Brent Ward, MD, DDS, FACS, assistant professor of oral and maxillofacial surgery and program director of Oncologic Maxillofacial/Head & Neck Surgery; Xue-min Cheng, Ph.D., research associate professor, Department of Internal Medicine and M-NiMBS; a medicinal chemist, Rameshwer Shukla, Ph.D., who is a research investigator in the Department of Internal Medicine and M-NiMBS; a medicinal chemist, Xiangyang Shi, Ph.D., who is a research investigator in the Department of Internal Medicine and M-NiMBS; a polymer chemist, Baohua Huang, Ph.D., who is a research investigator in the Department of Internal Medicine and M-NiMBS; a polymer chemist, Xiangdong Bi, Ph.D., Department of Internal Medicine and M-NiMBS; an organic chemist, Mark M. Banaszak Holl, Ph.D., professor of chemistry, applied physics and biophysics in the U-M College of Literature, Science, and the Arts, and of macromolecular science and engineering in the U-M College of Engineering; Ankur Desai, M.S., Department of Internal Medicine and M-NiMBS; an analytical chemist, Thommey P. Thomas, Ph.D., research assistant professor, Department of Internal Medicine and M-NiMBS; Bradford G. Orr, Ph.D., professor of physics in LS&A, director of the Academic Program in Applied Physics, and associate director of M-NiMBS; Alina Kotlyar, M.S., Department of Internal Medicine and M-NiMBS; and Thomas Dunham, B.S., of U-M Maxillofacial Surgery.

For more information on the U-M Nanotechnology Institute for Medicine and Biological Sciences, visit

Funding for the study comes from the Defense Advanced Research Projects Agency, part of the U.S. Department of Defense.

Patent applications have been filed on related U-M dendrimer inventions, which have been exclusively licensed to Avidimer Therapeutics, an Ann Arbor based biotech company in which Dr. Baker has a financial interest.


About University of Michigan Health System
We are among the country's top institutions in federally funded research. We are prominent in the pursuit of discovery, in the translation of pioneering breakthroughs to the clinical and business settings, and in the dissemination of new knowledge to health care providers and the public at large.

For more information, please click here

Anne Rueter


Copyright © University of Michigan Health System

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press


Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014


New star-shaped molecule breakthrough: Scientists at The University of Manchester have generated a new star-shaped molecule made up of interlocking rings, which is the most complex of its kind ever created September 22nd, 2014

Synthesis of Nanostructures with Controlled Shape, Size in Iran September 22nd, 2014

Iranian Scientists Separate Zinc Ion at Low Concentrations September 20th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Patents/IP/Tech Transfer/Licensing

‘Small’ transformation yields big changes September 16th, 2014

Berkeley Lab Licenses Boron Nitride Nanotube Technology: New material has unique mechanical and electronic properties September 13th, 2014

Secure Computing for the ‘Everyman': Quantum computing goes to market in tech transfer agreement with Allied Minds September 2nd, 2014

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014


Scientists refine formula for nanotube types: Rice University theorists determine factors that give tubes their chiral angles September 17th, 2014

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

'Squid skin' metamaterials project yields vivid color display: Rice lab creates RGB color display technology with aluminum nanorods September 15th, 2014

Fonon at Cutting-Edge of 3D Military Printing: Live-Combat Scenarios Could See a Decisive Advantage with 3D Printing September 15th, 2014


SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Big Results Require Big Ambitions: Three young UCSB faculty receive CAREER awards from the National Science Foundation September 18th, 2014

Effective Nanotechnology Innovations to Receive Mustafa Prize September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

The latest news from around the world, FREE

  Premium Products
Only the news you want to read!
 Learn More
University Technology Transfer & Patents
 Learn More
Full-service, expert consulting
 Learn More

Nanotechnology Now Featured Books


The Hunger Project

© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE