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June 17th, 2007
A unique nanoparticle made in a laboratory at the University of Central Florida is proving promising as a drug delivery device for treating glaucoma, an eye disease that can cause blindness and affects millions of people worldwide.
"The nanoparticle can safely get past the blood-brain barrier making it an effective non-toxic tool for drug delivery," said Sudipta Seal, an engineering professor with appointments in UCF's Advanced Materials Processing and Analysis Center and the Nanoscience Technology Center.
The findings will be published in an article appearing in the June 28 issue of the Journal of Physical Chemistry C.
Seal and his colleagues from North Dakota State University note in the article that while barely 1-3 percent of existing glaucoma medicines penetrate into the eye, earlier experiments with nanoparticles have shown not only high penetration rates but also little patient discomfort. The miniscule size of the nanoparticles makes them less abrasive than some of the complex polymers now used in most eye drops.
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