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June 14th, 2007
Cancer cells, like bacteria, can develop resistance to drug therapy. In fact, research suggests strongly that multidrug resistant cancer cells that remain alive after chemotherapy are responsible for the reappearance of tumors and the poor prognosis for patients whose cancer recurs. Indeed, multidrug resistance occurs in over 50% of patients whose ovarian cancer relapses, accounting in large part for the high mortality associated with ovarian cancer.
In an attempt to circumvent the mechanisms that cancer cells use to avoid cell death following chemotherapy, researchers at Northeastern University, led by Mansoor Amiji, Ph.D., have created a polymeric nanoparticle that delivers a one-two punch to multidrug resistant ovarian cancer cells.
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