Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Gelatin-Based Nanoparticle Effective in Gene Therapy for Breast Cancer

Abstract:
Northeastern University professor Mansoor Amiji and graduate student Sushma Kommareddy have published a new paper that examines the potential of engineered gelatin-based nanoparticles to deliver therapeutic genes to human breast cancer tumors implanted in mice.

Gelatin-Based Nanoparticle Effective in Gene Therapy for Breast Cancer

Boston, MA | Posted on April 13th, 2007

— Northeastern University professor Mansoor Amiji and graduate student Sushma Kommareddy have published a new paper that examines the potential of engineered gelatin-based nanoparticles to deliver therapeutic genes to human breast cancer tumors implanted in mice. Their research shows that these nanoparticles - or nanovectors - can serve as a safe and effective gene delivery vehicle to inhibit solid tumor growth. The paper is published in the most recent issue of Cancer Gene Therapy, available at: http://www.nature.com/cgt/index.html.

In the experiment, the nanoparticles were injected into the blood stream, and 15% of the dose found its way into the tumor, where it produced a protein, sFlt-1 or soluble receptor for an angiogenic factor, that cut off blood supply to the tumor.

"Essentially, what this treatment does," says Amiji, "is make the tumor a factory for its own destruction. The treatment shuts off the blood supply to a tumor - thereby effectively closing down the ‘road' for oxygen and nutrients to travel to the tumor and for cancerous cells to escape from the tumor and spread throughout the rest of the body."

In the past, this kind of gene delivery system had been attempted, but with viral vectors, which, although effective, are in many cases toxic to the recipient. Non-viral vectors for gene delivery applications are becoming increasingly popular owing to several advantages, which include lack of toxicity, no upper limit on the plasmid DNA size, and ease of manufacture.

"Non-viral gene therapy has tremendous promise when it comes to treating and curing diseases," says Amiji, "because you avoid the issues of toxicity that arise any time you introduce a viral element into the human body."

The researchers chose to work with gelatin in making the nanoparticles because it has a long history of safe use in the human body. In order to enhance the intracellular delivery potential of the gelatin, Northeastern researchers synthesized thiolated gelatin by covalent modification of the epsilon-amino groups of gelatin with 2-iminothiolane. Nanoparticles were then prepared with thiolated gelatin using a mild solvent exchange method that has been optimized in Northeastern laboratories.

In this study, the surface of both gelatin and thiolated gelatin nanoparticles was modified by reacting with methoxy-poly(ethylene glycol) (PEG)-succinimidyl glutarate to prolong in vivo circulation time - enabling the medication to stay in the body for up to 15 hours, a significant increase from just three hours with unmodified nanoparticles. PEG modification also enhanced tumor uptake and retention of the nanoparticles after administration.

Amiji notes that they are seeing positive results in pre-clinical studies and hope to begin clinical trials in the near future.

"We believe there are applications for this system of drug delivery in other diseases besides just cancer," said Amiji. "From heart disease and diabetes to glaucoma and macular degeneration, this is a versatile platform solution that could prove successful in a variety of applications."

"When I look at all of the drugs that are in clinical trials and some of the horrible side affects that patients must endure, all I can think is: We can do better - we must do better," says Amiji.

This study was supported by a grant from the National Cancer Institute of the National Institutes of Health (NIH).

####

About Northeastern University
Founded in 1898, Northeastern University is a private research university located in the heart of Boston, and a leader in interdisciplinary research, urban engagement, and the integration of classroom learning with real-world experience. Our signature cooperative education program, one of the largest and most innovative in the world, is ranked among the best in the nation by U.S. News & World Report. We offer a comprehensive range of undergraduate and graduate programs leading to degrees through the doctorate in six undergraduate colleges, eight graduate schools, and two part-time divisions.

For more information, please click here

Contacts:
Laura Shea
617-373-5427

Copyright © Newswise

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

Discoveries

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Announcements

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

Infrared instrumentation leader secures exclusive use of Vantablack coating December 5th, 2016

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Human Interest/Art

Weizmann Institute of Science Presents: Weizmann Wonder Wander - 4G - is Online June 21st, 2016

Call for NanoArt and Art-Science-Technology Papers June 9th, 2016

Scientists propose non-animal tools for assessing the toxicity of nanomaterials: Particle and Fibre Toxicology publishes recommendations from expert group meeting April 26th, 2016

Are humans the new supercomputer?Today, people of all backgrounds can contribute to solving serious scientific problems by playing computer games. A Danish research group has extended the limits of quantum physics calculations and simultaneously blurred the boundaries between mac April 14th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project