Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Gelatin-Based Nanoparticle Effective in Gene Therapy for Breast Cancer

Abstract:
Northeastern University professor Mansoor Amiji and graduate student Sushma Kommareddy have published a new paper that examines the potential of engineered gelatin-based nanoparticles to deliver therapeutic genes to human breast cancer tumors implanted in mice.

Gelatin-Based Nanoparticle Effective in Gene Therapy for Breast Cancer

Boston, MA | Posted on April 13th, 2007

— Northeastern University professor Mansoor Amiji and graduate student Sushma Kommareddy have published a new paper that examines the potential of engineered gelatin-based nanoparticles to deliver therapeutic genes to human breast cancer tumors implanted in mice. Their research shows that these nanoparticles - or nanovectors - can serve as a safe and effective gene delivery vehicle to inhibit solid tumor growth. The paper is published in the most recent issue of Cancer Gene Therapy, available at: http://www.nature.com/cgt/index.html.

In the experiment, the nanoparticles were injected into the blood stream, and 15% of the dose found its way into the tumor, where it produced a protein, sFlt-1 or soluble receptor for an angiogenic factor, that cut off blood supply to the tumor.

"Essentially, what this treatment does," says Amiji, "is make the tumor a factory for its own destruction. The treatment shuts off the blood supply to a tumor - thereby effectively closing down the ‘road' for oxygen and nutrients to travel to the tumor and for cancerous cells to escape from the tumor and spread throughout the rest of the body."

In the past, this kind of gene delivery system had been attempted, but with viral vectors, which, although effective, are in many cases toxic to the recipient. Non-viral vectors for gene delivery applications are becoming increasingly popular owing to several advantages, which include lack of toxicity, no upper limit on the plasmid DNA size, and ease of manufacture.

"Non-viral gene therapy has tremendous promise when it comes to treating and curing diseases," says Amiji, "because you avoid the issues of toxicity that arise any time you introduce a viral element into the human body."

The researchers chose to work with gelatin in making the nanoparticles because it has a long history of safe use in the human body. In order to enhance the intracellular delivery potential of the gelatin, Northeastern researchers synthesized thiolated gelatin by covalent modification of the epsilon-amino groups of gelatin with 2-iminothiolane. Nanoparticles were then prepared with thiolated gelatin using a mild solvent exchange method that has been optimized in Northeastern laboratories.

In this study, the surface of both gelatin and thiolated gelatin nanoparticles was modified by reacting with methoxy-poly(ethylene glycol) (PEG)-succinimidyl glutarate to prolong in vivo circulation time - enabling the medication to stay in the body for up to 15 hours, a significant increase from just three hours with unmodified nanoparticles. PEG modification also enhanced tumor uptake and retention of the nanoparticles after administration.

Amiji notes that they are seeing positive results in pre-clinical studies and hope to begin clinical trials in the near future.

"We believe there are applications for this system of drug delivery in other diseases besides just cancer," said Amiji. "From heart disease and diabetes to glaucoma and macular degeneration, this is a versatile platform solution that could prove successful in a variety of applications."

"When I look at all of the drugs that are in clinical trials and some of the horrible side affects that patients must endure, all I can think is: We can do better - we must do better," says Amiji.

This study was supported by a grant from the National Cancer Institute of the National Institutes of Health (NIH).

####

About Northeastern University
Founded in 1898, Northeastern University is a private research university located in the heart of Boston, and a leader in interdisciplinary research, urban engagement, and the integration of classroom learning with real-world experience. Our signature cooperative education program, one of the largest and most innovative in the world, is ranked among the best in the nation by U.S. News & World Report. We offer a comprehensive range of undergraduate and graduate programs leading to degrees through the doctorate in six undergraduate colleges, eight graduate schools, and two part-time divisions.

For more information, please click here

Contacts:
Laura Shea
617-373-5427

Copyright © Newswise

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

International research team discovers new mechanism behind malaria progression: Findings provide a new avenue for research in malaria treatment April 27th, 2015

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Discoveries

More is less in novel electronic material: Adding electrons actually shrinks the system April 27th, 2015

Two-dimensional semiconductor comes clean April 27th, 2015

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

Sensor Designed in Iran Able to Remove Formaldehyde Gas from Environment April 27th, 2015

Announcements

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

The 16th Trends in Nanotechnology International Conference (TNT 2015) unveils 25 Keynote Speakers: Call for abstracts open April 27th, 2015

Graphenea celebrates fifth anniversary April 27th, 2015

Sensor Designed in Iran Able to Remove Formaldehyde Gas from Environment April 27th, 2015

Human Interest/Art

To Conserve London's 300-Year-Old Masterpiece, Nanotech & Drones April 12th, 2015

2015 Nanonics Image Contest January 29th, 2015

OCSiAl supports NanoART Imagery Contest January 23rd, 2015

EnvisioNano: An image contest hosted by the National Nanotechnology Initiative (NNI) January 22nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project