Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Colorado State University engineers tissues to reduce use of animals in research

Abstract:
Colorado State University is engineering tissue in a laboratory that can replace the use of animals in research. The Tissue Engineering Laboratory, established this academic year in the College of Veterinary Medicine and Biomedical Sciences, creates tissue from a combination of cells, materials and biochemicals that model living biological systems. The model tissue replaces live animals in the initial phases of many biological studies, reducing the number of animals needed for use in research.

Colorado State University engineers tissues to reduce use of animals in research

FORT COLLINS, CO | Posted on April 9th, 2007

"As a researcher, I want to understand tissue cellular responses and develop a greater capacity to mitigate or prevent damage," said Dr. Tom Eurell, veterinarian and expert in toxicology and immunology and director of the laboratory. "As a veterinarian, I want to minimize or eliminate painful experiments in animals. Tissue engineering allows me to do both.

"It is impossible with current technology to model whole systems of human or animal response and repair, and to model systemic inflammation," Eurell said. "But we have the technology to be smarter about what we use and to refine our techniques for the benefit of both animals and humans."

For example, Eurell engineers artificial corneas. He uses corneas from already euthanized animals or human corneas donated to research as a "starter" to engineer more corneas by isolating stem cells from the corneas and growing new tissue in the lab. Each donated cornea can be used to create 20 to 25 artificial corneas. This reduces the need for live animals to test a variety of products and chemicals for eye irritants.

"We are trying to understand the best ways to help the eye repair itself following injury, and there are many things we don't know about this process," Eurell said. "For instance, we are interested in determining what happens to cornea cells after they have been exposed to lasers from therapeutic procedures such as LASIK or accidental exposure such as exposure to lasers during manufacturing processes. Engineering cornea tissue allows us to add one more tool to research rather than testing an initial concept on animals. We can use engineered tissues to assess the concept and determine from those results whether or not we should even move on to the next steps in research."

Eurell is working with human corneas donated from local surgery centers that do human corneal transplants to develop multiple corneas for research within the lab. These engineered corneas are used in the lab to study how the cornea actually functions when healing after injuries. By developing these models, Eurell can better understand how cells interact during the healing process.

In addition to researching cornea repair, Eurell also works with colleagues at Colorado State to research how lung cells react to airborne particles of different sizes, the use of nanotechnology to address health issues, proteins within cells, and substrate and cell interactions.

Tissue engineering has been used for some time to repair or replace hard tissues, such as bones, in human and veterinary patients. More recent developments in soft tissue research, including corneas, skin and muscle, can greatly reduce the number of animals used to test compounds and research tissue repair after trauma.

####

About Colorado State University
As one of our nation's leading research universities, Colorado State University is committed to realizing its vision as a 21st century land-grant university. Last year, CSU awarded degrees to over 5,000 graduates, attracted more than $220 million in research funding and contributed to the prosperity of Colorado and the nation with new graduates; advances in science, technology and learning; and community enrichment via the arts, humanities and the intellectual richness of a great research university.

CSU leads the world in such areas as infectious disease research, atmospheric science and environmental science. Its faculty members are tackling such issues as the reemergence of tuberculosis, the brown cloud of air pollution in Asian cities, severe weather forecasting, nutrition and wellness, and bioterrorism. Colorado State University is the “university of choice” for Colorado residents; 30% of all of Colorado’s science, math, engineering and technology majors study at CSU. In addition to its excellent programs in those areas, CSU offers among the very best professional programs in the United States in areas like veterinary medicine, occupational therapy, journalism, agriculture and construction management. Its programs in the arts, humanities and social sciences are also outstanding.

For more information, please click here

Contacts:
Dell Rae Moellenberg
(970) 491-6009

Copyright © Colorado State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Discoveries

Stanford breakthrough heralds super-efficient light-based computers: Light can transmit more data while consuming far less power than electricity, and an engineering feat brings optical data transport closer to replacing wires May 29th, 2015

Donuts, math, and superdense teleportation of quantum information May 29th, 2015

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

New chip makes testing for antibiotic-resistant bacteria faster, easier: Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time May 28th, 2015

Announcements

TCL Unveils First 65” TV Featuring QD Vision’s Color IQ™ Quantum Dot Technology: Emerging industry leader introduces expanded quantum dot TV lineup May 30th, 2015

Nanotech Secures Additional Patents in Advanced Security Features: New patented features gain attention from the banknote industry May 30th, 2015

New 'designer carbon' from Stanford boosts battery performance May 30th, 2015

Two UCSB Professors Receive Early Career Research Awards: The Department of Energy’s award for young scientists acknowledges UC Santa Barbara’s standing as a top tier research institution May 29th, 2015

Human Interest/Art

INSIDDE: Uncovering the real history of art using a graphene scanner May 21st, 2015

Winner Announced for NNI’s First ‘EnvisioNano’ Nanotechnology Image Contest May 6th, 2015

To Conserve London's 300-Year-Old Masterpiece, Nanotech & Drones April 12th, 2015

2015 Nanonics Image Contest January 29th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project