Nanotechnology Now - Press Release: Nanosys and Bruker Daltonics Announce NALDI™-TOF Collaboration

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Abstract:
Companies to Launch Nanotechnology-Enabled Small Molecule Chemical Analysis Chips for High-Throughput Laser Desorption Ionization Mass Spectrometry.

Nanosys and Bruker Daltonics Announce NALDI™-TOF Collaboration

PALO ALTO, CA & BILLERICA, MA | Posted on March 12th, 2007

Nanosys, Inc. and Bruker Daltonics Inc. today announced that they have entered into a broad R&D collaboration and distribution agreement for Nanosys' nanotechnology-enabled matrix-free target plates for use primarily with Bruker's FLEX™-series of laser desorption ionization (LDI) time-of-flight (TOF) mass spectrometers. These Nanosys plates are known as Capture and Analyze (CA) NALDI™ chips.

NALDI chips enable significant sensitivity, throughput and ease-of-use benefits for the analysis of small molecules such as drug compounds, small peptides, natural products, pesticides or many other low mass molecules that previously were difficult to analyze with the ease and throughput of MALDI-TOF mass spectrometers. Today, these molecules typically have to be analyzed with LC-MS (liquid chromatography - mass spectrometry), which is time-consuming, less robust and requires more operator training.

NALDI chips combined with robust, very fast, and exceptionally easy-to use TOF or TOF/TOF mass spectrometers have the potential to revolutionize small molecule mass spectrometry in many important areas of life science or chemical research and analysis. Potential applications areas include chemistry and molecular biology research, molecular diagnostics and molecular imaging research, pharma/biotech and other industrial research and analysis, as well as many applied fields, such as food analysis, environmental analysis, toxicology, etc.

Under the terms of the collaboration agreement, the companies will collaborate closely on R&D related to the NALDI chips, as well as on applications and assay development. Nanosys will manufacture and exclusively supply NALDI chips for Bruker LDI-TOF mass spectrometers, while Bruker Daltonics will market and distribute the innovative NALDI chips worldwide. Financial details of the agreement were not disclosed.

"We are excited to be partnering with Bruker Daltonics to bring our NALDI chip products to market," said Calvin Chow, Nanosys' Chief Executive Officer. "Bruker is a clear leader in the area of chemical analysis and life sciences research. They understand how to take breakthrough technology products successfully into high value markets."

Frank Laukien, Ph.D., President and CEO of Bruker Daltonics, commented: "The unique capabilities offered by the Nanosys NALDI chips in combination with our industry-leading TOF and TOF/TOF mass spectrometers open up a breadth of new research and applied market opportunities for the easy, fast and robust analysis of small molecules. We are very pleased to be working with Nanosys to deploy their practical and enabling expertise in nanotechnology to address these new areas."

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About Nanosys
Nanosys, Inc. is a leader in the development of nanotechnology enabled products utilizing high performance inorganic nanostructures. Nanosys has built one of the broadest technology platforms in the industry with approximately 500 patents and patent applications covering fundamental areas of nanotechnology. Based in Palo Alto, California and privately held, Nanosys collaborates with industry leaders to develop revolutionary high-value, high-performance products for computing, optoelectronics, communications, renewable energy, defense and the life sciences. Additional information on Nanosys can be found at http://www.nanosysinc.com .

ABOUT BRUKER BIOSCIENCES (NASDAQ: BRKR)

Bruker BioSciences Corporation in Billerica, Massachusetts, is the parent company of Bruker AXS Inc., Bruker Daltonics Inc. and Bruker Optics, Inc. Bruker AXS is a leading developer and provider of life science, materials research and industrial X-ray analysis and spark-OES tools. Bruker Daltonics is a leading developer and provider of innovative life science tools based on mass spectrometry, and also offers a broad line of chemical, biological, radiological and nuclear (CBRN) detection products for homeland security. Bruker Optics is a leading developer, manufacturer and provider of research, analytical and process analysis instruments and solutions based on infrared and Raman molecular spectroscopy technology. For more information, please visit http://www.bruker-biosciences.com .

CAUTIONARY STATEMENT OF BRUKER BIOSCIENCES

Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. Any forward-looking statements contained herein are based on current expectations, but are subject to a number of risks and uncertainties. The factors that could cause actual future results to differ materially from current expectations include, but are not limited to, risks and uncertainties relating to our reorganization strategies, risks related to the integration of businesses we have acquired or may acquire in the future, technological approaches, product development, market acceptance, cost and pricing of our products, changes in governmental regulations, capital spending and government funding policies, FDA and other regulatory approvals to the extent applicable, competition, the intellectual property of others, patent protection and litigation. These and other factors are identified and described in more detail in our filings with the SEC, including, without limitation, our annual report on Form 10-K for the year ended December 31, 2005, our most recent quarterly reports on Form 10-Q, our S-3/A filed on January 29, 2007 and our current reports on Form 8-K. We disclaim any intent or obligation to update these forward-looking statements.

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Contacts:
Nanosys:
Peter Garcia, 650-331-2154
Chief Financial Officer

or
Bruker Daltonics:
Michael Willett, 978-663-3660, ext. 1411
Investor Relations and Public Relations Officer

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