Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > News > The challenge of designing nanomaterials with reduced toxicity

March 1st, 2007

The challenge of designing nanomaterials with reduced toxicity

Abstract:
Obtaining an understanding, at the atomic level, of the interaction of nanomaterials with biological systems has recently become an issue of great research interest. Nanomaterials can exhibit drastically different characteristics compared to their bulk counterparts. Although the use of such materials in biological systems opens avenues for the creation of novel biosensing and alternative nanomedical technologies, these nanomaterials can also be highly toxic. A greater understanding of the interaction of nanomaterials with biological systems, especially of the interaction of nanomaterials with cell membranes, will enable scientists to take full advantage of the unique properties of nanomaterials while minimizing their adverse effects. Fullerenes and their derivatives are an important subset of nanomaterials. Fullerenes have been used as robust oxygen scavengers, anti-HIV drugs, X-ray contrast agents, and transporters for delivering antibodies. While experimental studies suggest that the toxicity of nanomaterials depends critically on their surface properties, it was also found that, in the case of fullerenes, functionalizing the molecules can reduce their toxicity notably. New work by U.S. researchers offers a mechanistic view on the different cytotoxicity of fullerenes and their functionalized derivatives - a first in this important field of nanotoxicity. The major finding is that pristine fullerene can readily jump into a lipid bilayer while the translocation of a functionalized fullerene is severely hindered due to its surface charge, leading to a much reduced toxicity.

Source:
nanowerk.com

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Discoveries

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

Safety-Nanoparticles/Risk management

Warning to DIY enthusiasts & construction workers as dangerous dust emissions August 19th, 2015

Bionic liver micro-organs explain off-target toxicity of acetaminophen (Tylenol): Israeli-German partnership aims to replace animal experiments with advanced liver-on-chip devices August 17th, 2015

Sediment dwelling creatures at risk from nanoparticles in common household products August 13th, 2015

Proving nanoparticles in sunscreen products August 4th, 2015

Human Interest/Art

Bionic liver micro-organs explain off-target toxicity of acetaminophen (Tylenol): Israeli-German partnership aims to replace animal experiments with advanced liver-on-chip devices August 17th, 2015

Omni Nano and Time Warner Cable Partner to Provide Nanotechnology Education to the Boys & Girls Clubs of Los Angeles: A $10,000 Donation to Benefit Youth of Los Angeles County's Boys & Girls Clubs August 4th, 2015

Kalam: versatility personified August 1st, 2015

Pakistani Students Who Survived Terror Attack to Attend Weeklong “NanoDiscovery Institute” at SUNY Poly CNSE in Albany July 29th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic