Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > News > The challenge of designing nanomaterials with reduced toxicity

March 1st, 2007

The challenge of designing nanomaterials with reduced toxicity

Abstract:
Obtaining an understanding, at the atomic level, of the interaction of nanomaterials with biological systems has recently become an issue of great research interest. Nanomaterials can exhibit drastically different characteristics compared to their bulk counterparts. Although the use of such materials in biological systems opens avenues for the creation of novel biosensing and alternative nanomedical technologies, these nanomaterials can also be highly toxic. A greater understanding of the interaction of nanomaterials with biological systems, especially of the interaction of nanomaterials with cell membranes, will enable scientists to take full advantage of the unique properties of nanomaterials while minimizing their adverse effects. Fullerenes and their derivatives are an important subset of nanomaterials. Fullerenes have been used as robust oxygen scavengers, anti-HIV drugs, X-ray contrast agents, and transporters for delivering antibodies. While experimental studies suggest that the toxicity of nanomaterials depends critically on their surface properties, it was also found that, in the case of fullerenes, functionalizing the molecules can reduce their toxicity notably. New work by U.S. researchers offers a mechanistic view on the different cytotoxicity of fullerenes and their functionalized derivatives - a first in this important field of nanotoxicity. The major finding is that pristine fullerene can readily jump into a lipid bilayer while the translocation of a functionalized fullerene is severely hindered due to its surface charge, leading to a much reduced toxicity.

Source:
nanowerk.com

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Discoveries

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Candy cane supercapacitor could enable fast charging of mobile phones August 17th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Candy cane supercapacitor could enable fast charging of mobile phones August 17th, 2017

Safety-Nanoparticles/Risk management

Tests show no nanotubes released during utilisation of nanoaugmented materials June 9th, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

NIST updates 'sweet' 1950s separation method to clean nanoparticles from organisms January 27th, 2017

Nanoparticle exposure can awaken dormant viruses in the lungs January 17th, 2017

Human Interest/Art

Weizmann Institute of Science Presents: Weizmann Wonder Wander - 4G - is Online June 21st, 2016

Call for NanoArt and Art-Science-Technology Papers June 9th, 2016

Scientists propose non-animal tools for assessing the toxicity of nanomaterials: Particle and Fibre Toxicology publishes recommendations from expert group meeting April 26th, 2016

Are humans the new supercomputer?Today, people of all backgrounds can contribute to solving serious scientific problems by playing computer games. A Danish research group has extended the limits of quantum physics calculations and simultaneously blurred the boundaries between mac April 14th, 2016

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project