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Home > News > Thermal Dosimetry Predictive of Efficacy of 111In-ChL6 Nanoparticle AMF–Induced Thermoablative Therapy for Human Breast Cancer in Mice

March 1st, 2007

Thermal Dosimetry Predictive of Efficacy of 111In-ChL6 Nanoparticle AMF–Induced Thermoablative Therapy for Human Breast Cancer in Mice

Abstract:
Antibody (mAb)-linked iron oxide nanoparticles (bioprobes) provide the opportunity to develop tumor specific thermal therapy (Rx) for metastatic cancer when inductively heated by an externally applied alternating magnetic field (AMF). To evaluate the potential of this Rx, in vivo tumor targeting, efficacy, and predictive radionuclide-based heat dosimetry were studied using 111In-ChL6 bioprobes (ChL6 is chimeric L6) in a human breast cancer xenograft model.

Source:
jnm.snmjournals.org

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