Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > MIT nanoparticles may help detect, treat tumors

Abstract:
Technique may one day help physicians detect cancerous tumors in early stages

MIT nanoparticles may help detect, treat tumors

Cambridge, MA | Posted on May 01, 2006

A new technique devised by MIT engineers may one day help physicians detect cancerous tumors during early stages of growth.

The technique allows nanoparticles to group together inside cancerous tumors, creating masses with enough of a magnetic signal to be detectable by a magnetic resonance imaging (MRI) machine.

The work appears as the cover feature in the May issue of Angewandte Chemie International Edition, one of the world's leading chemistry journals.

The research, which is just moving into animal testing, involves injecting nanoparticles (billionths of a meter in size) made of iron oxide into the body, where they flow through the bloodstream and enter tumors.

Solid tumors must form new blood vessels to grow. But because this growth is so rapid in cancerous tumors, there are gaps in the endothelial cells that line the inside of the blood vessels. The nanoparticles can slip through these gaps to enter the tumors.

Once inside the tumor, the nanoparticles can be triggered to group together by a mechanism designed by the MIT engineers. Specifically, certain enzymes, or proteases, inside the tumors cause the nanoparticles to "self-assemble" or stick together. The resulting nanoparticle clumps are too big to get back out of the gaps. Further, the clumps have a stronger magnetic signal than do individual nanoparticles, allowing detection by MRI.

"We inject nanoparticles that will self-assemble when they are exposed to proteases inside of invasive tumors," said Sangeeta N. Bhatia, M.D., Ph.D., associate professor of the Harvard-MIT Division of Health Sciences & Technology (HST) and Electrical Engineering and Computer Science (EECS). "When they assemble they should get stuck inside the tumor and be more visible on an MRI. This might allow for noninvasive imaging of fast-growing cancer 'hot spots' in tumors." Bhatia also is affiliated with the MIT-Harvard Center of Cancer Nanotechnology Excellence.

The technique initially is being used to study breast tumors. Bhatia added that it eventually may be applied to many different types of cancers and to study the "triggers" that turn a benign mass in the body into a cancerous tumor. Nanoparticles also hold the promise of carrying medicines that could kill cancer cells, replacing radiation or chemotherapy treatments that cause negative side effects such as hair loss or nausea.

The researchers hold a provisional patent on their work.

Co-authors on the paper are Todd Harris and Geoffrey von Maltzahn, HST graduate students; Austin Derfus, a graduate student at the University of California at San Diego; and Erkki Ruoslahti, M.D., Ph.D., a professor at The Burnham Institute in LaJolla, Calif.

The work was supported by the National Cancer Institute, the National Aeronautics and Space Administration and the Whitaker Foundation.

Contact:
Elizabeth A. Thomson
MIT News Office
617-258-5402
thomson@mit.edu

Copyright © MIT

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Possible Futures

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Harris & Harris Group Portfolio Company D-Wave Systems Announces 1,000 Qubit Processor and is Discussed in the Economist June 23rd, 2015

Global Nanoclays Market Analysis, Size, Growth, Trends And Segment Forecasts, 2015 To 2022: Grand View Research, Inc June 15th, 2015

Self Assembly

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

New conductive ink for electronic apparel June 25th, 2015

Giving atoms their marching orders: Highly homogeneous nanotube enforces single-file flow of atoms in gas diffusion. Direct comparison of single-file and Fickian diffusion possible with new system described by researchers at the University of South Carolina and University of Flor June 24th, 2015

n-tech Research Issues Report on Smart Coatings Market, Free Download Available on Firmís Website June 24th, 2015

Nanomedicine

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Materials/Metamaterials

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Production of Zirconium Carbide Nanoparticles at Low Temperature without Thermal Operations July 5th, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

New technology using silver may hold key to electronics advances July 2nd, 2015

Announcements

Surfing a wake of light: Researchers observe and control light wakes for the first time July 6th, 2015

Tel Aviv/Tsinghua University project uses crowd computing to improve water filtration: The research, a product of the new TAU-Tsinghua XIN Center, was conducted by 150,000 volunteers at IBM's World Community Grid July 6th, 2015

Transition from 3 to 2 dimensions increases conduction, MIPT scientists discover July 6th, 2015

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

Patents/IP/Tech Transfer/Licensing

GLOBALFOUNDRIES Completes Acquisition of IBM Microelectronics Business: Transaction adds differentiating technologies, world-class technologists, and intellectual property July 1st, 2015

NEI Announces the Issuance of Multiple Patents on Self-Healing & Superhydrophobic Coatings June 30th, 2015

Solegear Further Strengthens its Product Development Team: New Hire Seeks to Create New, Disruptive, Sustainable Materials June 17th, 2015

High-tech nanofibres could help nutrients in food hit the spot June 17th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project