Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > UC Santa Cruz researchers receive $1.6M grant

Abstract:
"The nanopore will act as a smart gate for entry of individual molecules into the channel of the waveguide"

UC Santa Cruz researchers receive $1.6 million grant for biosensor project

Posted on March 29, 2006

Researchers at the University of California, Santa Cruz, have received major funding from the National Institutes of Health to develop new sensor technology for biomedical applications. The project builds on earlier advances by UCSC researchers in optical and electrical sensing technologies and involves a broad interdisciplinary group of collaborators at UCSC and Brigham Young University.

Holger Schmidt, an associate professor of electrical engineering at UCSC, is principal investigator on the grant from the National Institute of Biomedical Imaging and Bioengineering, which will provide $1.6 million over four years for the sensor project.

"We aim to develop a new type of instrument that can do both electrical and optical sensing of single biomolecules, with all the components of the sensor ultimately integrated onto a chip," Schmidt said. "This would be the first device to provide both electrical and optical characterization of single molecules."

Potential applications for the new device include highly sensitive testing for medical diagnostics. It could also be a powerful tool for basic research in molecular biology.

In 2004, Schmidt and his coworkers reported the first demonstration of integrated optical waveguides with liquid cores. This technology, using the principle of antiresonant reflecting optical waveguides (ARROW), enables light propagation through tiny volumes of liquids on a chip. Since then, Schmidt has continued to work with Aaron Hawkins of Brigham Young University to optimize the properties of the liquid-core optical waveguides for use in sensor devices. The new project involves the collaboration of two other scientists at UCSC: David Deamer, professor of chemistry and biochemistry and acting chair of biomolecular engineering, and Harry Noller, Sinsheimer Professor of Molecular Biology.

Deamer has pioneered the development of nanopore devices for electrical sensing of single molecules. A nanopore is a tiny hole with dimensions on the order of nanometers (a nanometer is one billionth of a meter). Passage of a molecule through the hole generates a characteristic electrical signal. The team plans to integrate nanopores and liquid-core optical waveguides into the new sensor platform.

"The nanopore will act as a smart gate for entry of individual molecules into the channel of the waveguide," Schmidt said.

Noller is a leading authority on ribosomes, complex biomolecular machines that are the protein factories in all living cells. The researchers will use the new sensor platform to study individual ribosomes in action.

"In the integrated sensor, we will be able to study the ribosome without the need to immobilize it, so we hope to gain new understanding of how the ribosome works," Schmidt said.

The collaboration brings together researchers from three different departments at UCSC: the Departments of Electrical Engineering and Biomolecular Engineering, both in the Baskin School of Engineering, and the Department of Molecular, Cell, and Developmental Biology in the Division of Physical and Biological Sciences.

"This is a truly multidisciplinary collaboration," Schmidt said. "I am very excited about using integrated optics to investigate real problems in molecular biology."

####


Note to reporters: You may contact Schmidt at (831) 459-1482 or hschmidt@soe.ucsc.edu



Media Contact:
Tim Stephens
(831) 459-2495
stephens@ucsc.edu

Copyright © University of California, Santa Cruz

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Possible Futures

Simulations predict flat liquid May 21st, 2015

Nature inspires first artificial molecular pump: Simple design mimics pumping mechanism of life-sustaining proteins found in living cells May 19th, 2015

NNCO and Museum of Science Fiction to Collaborate on Nanotechnology and 3D Printing Panels at Awesome Con May 19th, 2015

Quantum 'gruyères' for spintronics of the future: Topological insulators become a little less 'elusive' May 12th, 2015

Investments/IPO's/Splits

Evident Thermoelectrics Acquires GMZ Energy: Investment Accelerates Launch Of Evident's Thermoelectric Modules For Waste Heat May 20th, 2015

Nanometrics Announces Live Webcast of Upcoming Investor and Analyst Day May 20th, 2015

PEN Inc. Announces First Quarter Financial Results: Investor Webcast and Business Update Set for May 21, 1 pm EDT May 13th, 2015

Harris & Harris Group Portfolio Company OpGen Raises $17.1 Million in Initial Public Offering May 6th, 2015

Nanomedicine

Nanostructures Increase Corrosion Resistance in Metallic Body Implants May 24th, 2015

Iranian Scientists Use Magnetic Field to Transfer Anticancer Drug to Tumor Tissue May 24th, 2015

New Antibacterial Wound Dressing in Iran Can Display Replacement Time May 22nd, 2015

Researchers develop new way to manufacture nanofibers May 21st, 2015

Sensors

This Slinky lookalike 'hyperlens' helps us see tiny objects: The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists' ability to observe single molecules May 23rd, 2015

Record high sensitive Graphene Hall sensors May 21st, 2015

Graphene enables tunable microwave antenna May 15th, 2015

Janusz Bryzek Joins MEMS Industry Group to Lead New TSensors Division - New Division will Focus on Accelerating Development of Emerging Ultra-high Volume Sensors Supporting Abundance, mHealth and IoT May 14th, 2015

Announcements

Nanostructures Increase Corrosion Resistance in Metallic Body Implants May 24th, 2015

Iranian Scientists Use Magnetic Field to Transfer Anticancer Drug to Tumor Tissue May 24th, 2015

Basel physicists develop efficient method of signal transmission from nanocomponents May 23rd, 2015

This Slinky lookalike 'hyperlens' helps us see tiny objects: The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists' ability to observe single molecules May 23rd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project