Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > UC Santa Cruz researchers receive $1.6M grant

Abstract:
"The nanopore will act as a smart gate for entry of individual molecules into the channel of the waveguide"

UC Santa Cruz researchers receive $1.6 million grant for biosensor project

Posted on March 29, 2006

Researchers at the University of California, Santa Cruz, have received major funding from the National Institutes of Health to develop new sensor technology for biomedical applications. The project builds on earlier advances by UCSC researchers in optical and electrical sensing technologies and involves a broad interdisciplinary group of collaborators at UCSC and Brigham Young University.

Holger Schmidt, an associate professor of electrical engineering at UCSC, is principal investigator on the grant from the National Institute of Biomedical Imaging and Bioengineering, which will provide $1.6 million over four years for the sensor project.

"We aim to develop a new type of instrument that can do both electrical and optical sensing of single biomolecules, with all the components of the sensor ultimately integrated onto a chip," Schmidt said. "This would be the first device to provide both electrical and optical characterization of single molecules."

Potential applications for the new device include highly sensitive testing for medical diagnostics. It could also be a powerful tool for basic research in molecular biology.

In 2004, Schmidt and his coworkers reported the first demonstration of integrated optical waveguides with liquid cores. This technology, using the principle of antiresonant reflecting optical waveguides (ARROW), enables light propagation through tiny volumes of liquids on a chip. Since then, Schmidt has continued to work with Aaron Hawkins of Brigham Young University to optimize the properties of the liquid-core optical waveguides for use in sensor devices. The new project involves the collaboration of two other scientists at UCSC: David Deamer, professor of chemistry and biochemistry and acting chair of biomolecular engineering, and Harry Noller, Sinsheimer Professor of Molecular Biology.

Deamer has pioneered the development of nanopore devices for electrical sensing of single molecules. A nanopore is a tiny hole with dimensions on the order of nanometers (a nanometer is one billionth of a meter). Passage of a molecule through the hole generates a characteristic electrical signal. The team plans to integrate nanopores and liquid-core optical waveguides into the new sensor platform.

"The nanopore will act as a smart gate for entry of individual molecules into the channel of the waveguide," Schmidt said.

Noller is a leading authority on ribosomes, complex biomolecular machines that are the protein factories in all living cells. The researchers will use the new sensor platform to study individual ribosomes in action.

"In the integrated sensor, we will be able to study the ribosome without the need to immobilize it, so we hope to gain new understanding of how the ribosome works," Schmidt said.

The collaboration brings together researchers from three different departments at UCSC: the Departments of Electrical Engineering and Biomolecular Engineering, both in the Baskin School of Engineering, and the Department of Molecular, Cell, and Developmental Biology in the Division of Physical and Biological Sciences.

"This is a truly multidisciplinary collaboration," Schmidt said. "I am very excited about using integrated optics to investigate real problems in molecular biology."

####


Note to reporters: You may contact Schmidt at (831) 459-1482 or hschmidt@soe.ucsc.edu



Media Contact:
Tim Stephens
(831) 459-2495
stephens@ucsc.edu

Copyright University of California, Santa Cruz

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Possible Futures

EmTech Asia breaks new barriers with potential applications of space exploration with NASA and MIT February 22nd, 2017

Tiny nanoclusters could solve big problems for lithium-ion batteries February 21st, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

Breakthrough with a chain of gold atoms: In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport February 20th, 2017

Investments/IPO's/Splits

Harris & Harris Group Announces the Filing of Preliminary Proxy Materials Detailing Its Proposed Conversion From a BDC to a Registered Closed-End Fund January 24th, 2017

Harris & Harris Group Issues Reminder for Shareholder Update Call on January 10, 2017 January 10th, 2017

Arrowhead Provides Response to New Minority Shareholder Announcement January 7th, 2017

Harris & Harris Group Announces a Proposed Strategic Restructuring December 20th, 2016

Nanomedicine

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Sensors

Strem Chemicals and Dotz Nano Ltd. Sign Distribution Agreement for Graphene Quantum Dots Collaboration February 21st, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Research opens door to smaller, cheaper, more agile communications tech February 16th, 2017

Metamaterial: Mail armor inspires physicists: KIT researchers reverse hall coefficient -- medieval mail armor inspired development of metamaterial with novel properties February 15th, 2017

Announcements

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Particle Works creates range of high performance quantum dots February 23rd, 2017

GLOBALFOUNDRIES Announces Availability of 45nm RF SOI to Advance 5G Mobile Communications: Optimized RF features deliver high-performance solutions for mmWave beam forming applications in 5G smartphones and base stations February 22nd, 2017

EmTech Asia breaks new barriers with potential applications of space exploration with NASA and MIT February 22nd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project