Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanoparticle as diagnostic, therapeutic agent

Abstract:
Virginia Tech researchers create nanoparticle as diagnostic, therapeutic agent; Virginia Commonwealth University researchers target brain tumor cells

Nanoparticle as diagnostic, therapeutic agent

Blacksburg, VA | October 19, 2005

Researchers working with a man-made, metal-filled nanoparticle are developing the material for use as a diagnostic and therapeutic agent that may boost the sensitivity of MRI techniques and improve the diagnosis and treatment of brain tumors.

Panos Fatouros, a professor in the Department of Radiology at Virginia Commonwealth University, has been awarded a five-year, $3.7 million grant from the National Institutes of Health's National Cancer Institute to lead a team of scientists from VCU and Virginia Tech. In a cooperative effort, they will work to further develop, produce, and test nanoparticles that can identify brain tumor cells and selectively target them for radiation therapy.

Harry Dorn, and Harry Gibson, both chemistry professors at Virginia Tech College of Science, along with other colleagues created a nanoparticle called a functional metallofullerene (fMF) that will serve as the basis for the proposed research. It is envisioned that this research will generate a multi-functional platform that will integrate diagnostic and therapeutic functions.

"The metal-filled nanoparticles developed by our colleagues at Virginia Tech, and the advances in imaging, molecular biology and drug delivery at VCU, have opened the possibility for combined targeted diagnosis and therapy of tumors and their infiltrative aspects," said Fatouros. In effect, one can look at these nanoparticles as targeted drug delivery vehicles.

Tumor cells that extend beyond the well-defined tumor margins are often impossible to visualize with current imaging techniques. According to Fatouros, this research may one day benefit patients with advanced brain tumors by enabling treatment of tumor cells that have spread beyond the visible margins of the tumor on CT and MRI scans. Fatouros said that these tumor cells are most likely to result in recurrence of the brain tumor and that improved methods of attacking these cells offer the possibility of delaying or preventing brain tumor relapse.

Fullerenes are hollow carbon cage-like molecules that were discovered in the 1970s. Popularly known as "buckyballs," they are a third form of carbon; the others are graphite and diamond. For decades, scientists attempted to put atoms with useful properties inside these cages. In 1999, Dorn and his colleagues succeeded and were able to encapsulate rare earth metals in the hollow interior of these nanoparticles that can easily be recognized by MRI techniques. They created useful quantities of these metal-filled fullerenes and changed their shape, creating an entire family of metallofullerenes.

In 2002, when Dorn's Ph.D. student, Erick Iezzi discovered how to add organic reagents to the exterior of the carbon cage and make the molecule water soluble. Gibson has since created a multitude of ways to attach guest molecules to the fullerene host, so the fMFs can attach to disease sites in a variety of ways, perhaps as photodynamic therapy agents.

Preliminary experiments conducted in the VCU labs of Fatouros and William Broaddus, a neurosurgeon at VCU, using rat models and the buckyballs created by Dorn and Gibson have shown some promise. These researchers have used the nanoparticles in novel imaging and drug delivery methods to detect tumors implanted in a rat's brain. They found that the nanoparticles highlighted the tumors more effectively than existing imaging agents. The fMF material provides improved brain tissue differentiation and a dark outline of the tumor margin, making surgical removal more precise. These preliminary results will be published in the scientific journal, Radiology.

In addition the VCU-Virginia Tech team also has demonstrated that when using the fMF as a contrast agent for MRI examinations, the material is at least 40 times more effective than current commercial agents.

The Virginia Tech researchers plan to load the fMFs with a metal that can be neutron activated to produce useful radioisotopes and fluorescent materials. Some of this work will be conducted at the Oak Ridge National Lab. "We will make the fMFs radioactive so they can be used in treatment and make the fmFs fluoresce so the doctors can track it and watch the tumor shrink," Dorn said. These particles will be further modified by the VCU-Virginia Tech teams to target cancer cells.

Fatouros will be collaborating with colleagues in the VCU departments of radiology, neurosurgery, anatomy and neurobiology, and physics. Individuals include Corwin Frank; John Wilson; Joseph Kalen; Birgit Kettenmann; James Tatum; William Broaddus; Helen Fillmore; Zhi-Jang Chen; Scott Henderson; and Shiv Khanna. The research at Virginia Tech is being conducted by and Dorn and Gibson and their students. James Duchamp of Emory and Henry College has also been a frequent collaborator with Dorn. In addition, further research will be carried out at the Jefferson National Lab and Oak Ridge National Laboratory. Dorn has also been awarded $600,000 by the NSF to head a Nanoscale Interdisciplinary Research Team (NIRT) to optimize the nanosphere platform for high-resolution multi-modailty imaging applications. This project includes Chris Wyatt, faculty member of electrical and computer engineering at Virginia Tech. And Gibson has received significant NSF funding for his research on self-assembly of complex molecules.

####
Contact:
Susan Trulove
(540) 231-5646
strulove@vt.edu

Copyright © Virginia Tech

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Possible Futures

Harris & Harris Group Portfolio Company D-Wave Systems Announces 1,000 Qubit Processor and is Discussed in the Economist June 23rd, 2015

Global Nanoclays Market Analysis, Size, Growth, Trends And Segment Forecasts, 2015 To 2022: Grand View Research, Inc June 15th, 2015

Healthcare Nanotechnology (Nanomedicine) Market Size To 2020 June 5th, 2015

Environmental Issues to Hamper Growth of Global Nanocomposites Market June 4th, 2015

Investments/IPO's/Splits

Harris & Harris Group Portfolio Company, AgBiome, Announces Partnership to Accelerate the Discovery of Next Generation Insect-Resistant Crops July 1st, 2015

Nanometrics to Participate in 7th Annual CEO Investor Summit 2015: Investor Event Held Concurrently With SEMICON West in San Francisco June 25th, 2015

Harris & Harris Group Portfolio Company D-Wave Systems Announces 1,000 Qubit Processor and is Discussed in the Economist June 23rd, 2015

Nanowire LED Innovator Aledia Completes $31 Million Series B Financing June 18th, 2015

Nanomedicine

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015

Researchers from the UCA, key players in a pioneering study that may explain the origin of several digestive diseases June 30th, 2015

Materials/Metamaterials

Proposed TSCA Nanomaterial Rule ‘Premature’, Says Former EPA Toxicologist July 1st, 2015

NEI Announces the Issuance of Multiple Patents on Self-Healing & Superhydrophobic Coatings June 30th, 2015

BASF and Fraunhofer IPMS-CNT jointly develop electronic materials June 30th, 2015

Green Chemistry Methods Used in Iran to Produce Zinc Oxide Nanoparticles June 27th, 2015

Announcements

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Bruker Introduces Second-Generation Inspire Nanochemical Imaging Solution: Featuring Unique PeakForce IR and IR EasyAlign Technology July 1st, 2015

GLOBALFOUNDRIES Completes Acquisition of IBM Microelectronics Business: Transaction adds differentiating technologies, world-class technologists, and intellectual property July 1st, 2015

Samsung's New Graphene Technology Will Double Life Of Your Lithium-Ion Battery July 1st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project