Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Stealth Particles to Target Tumors

Abstract:
Stealth targeting drug delivery system could also deliver genes or gene fragments in gene therapy

Stealth Particles to Target Tumors

Washington, D.C. | August 31, 2005

Stealth nano particles may some day target tumor cells and deliver medication to specific body locations, according to Penn State chemical engineers.

"Mainly we have focused on chemotherapy drugs," says Dr. Michael Pishko, professor of chemical engineering and materials science and engineering. "But others are considering using this delivery system to deliver genes in gene therapy."

The researchers first produce nano-sized powders of the drug they wish to deliver and encapsulate them in a polymer nanoshell. The drug used for this project was paclitaxel -≠ an anti breast cancer drug ≠ and dexamethasone -≠ a steroid frequently used to treat eye inflammation. This shell allows the drug to travel in stealth mode through the bloodstream.

"A layer-by-layer self-assembly technique was used to encapsulate core charged drug nanoparticles in a polymeric nanoshell," the researchers told attendees today (Aug. 31) at the 230th American Chemical Society Meeting, Washington, D.C.

Normally, drugs, especially the toxic drugs used for chemotherapy, trigger the human immune system into action, but, with the polymer shell for protection, these drugs can circulate longer without being removed.

"If the drugs do not trigger an immune response, then lower levels of drug can be used than currently are necessary in chemotherapy," says Pishko.

The researchers, who include Pishko, Alisar Zahr and Cheryl A. Rumbarger, graduate students in chemical engineering, tested their nanoshell in cell culture and found that it had less phagocytosis ≠ removal of the drug ≠ during a 24-hour period than the unencapsulated drug.

Combined with longer retention in the body, the researchers engineered the nanoparticle shells to target specific cells by attaching a functionalized polymer to the shell. They designed this tentacle-like projection to target a receptor on a tumor cell, or a specific location in the eye, for example. Once the drug arrives via the blood to the tumor or eye, it attaches and slowly releases its contents.

This type of drug delivery system works especially well in such highly vascularized areas such as tumors and the eye, because the drug can travel right up to the target area. Delivery to areas in the brain would not be feasible because of the blood brain barrier that prevents foreign substances from moving from the blood into the cells of the brain.

"For targeting, we could exploit the fact that cancer tumors have a lot more folic acid receptors and target those," says Pishko. "We could also use specific monoclonal antibodies to target specific tumors."

The researchers also considered delivery of drugs to specific type cells, like those in the eye. This type of stealth targeting drug delivery system could also deliver genes or gene fragments in gene therapy.

The National Science Foundation funded this research.

####
Contact:
A'ndrea Elyse Messer
Science & Research Information Officer Penn State
814-865-9481
814-865-9421
aem1@psu.edu

Copyright © Penn State

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Possible Futures

Smart multi-layered magnetic material acts as an electric switch: New study reveals characteristic of islands of magnetic metals between vacuum gaps, displaying tunnelling electric current March 1st, 2017

Bioinspired process makes materials light, robust, programmable at nano- to macro-scale: Ultralight web of silk nano fibers withstands load 4,000 times its weight February 28th, 2017

Nano 'sandwich' offers unique properties: Rice University researchers simulate two-dimensional hybrids for optoelectronics February 27th, 2017

Sandia use confined nanoparticles to improve hydrogen storage materials performance: Big changes from a small package for hydrogen storage February 25th, 2017

Self Assembly

Molecular phenomenon discovered by advanced NMR facility: Cutting edge technology has shown a molecule self-assembling into different forms when passing between solution state to solid state, and back again - a curious phenomenon in science - says research by the University of Wa February 22nd, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Synthetic nanoparticles achieve the complexity of protein molecules: Study published in Science reveals the structure of the largest gold nanoparticles to-date and the self-assembly mechanisms behind their formation January 25th, 2017

Self-assembling particles brighten future of LED lighting January 18th, 2017

Nanomedicine

Biosensors: Distance makes the signal grow stronger March 1st, 2017

NovAliX Turns to High-Resolution Cryo-Transmission Electron Microscopy for Pre-Clinical Drug Discovery Research: Thermo Fisher Scientificís Cryo-TEM provides critical information for small molecule and biologic drug discovery February 28th, 2017

New nano approach could cut dose of leading HIV treatment in half February 24th, 2017

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Announcements

Triboelectric Nanogenerators Boost Mass Spectrometry Performance March 1st, 2017

Biosensors: Distance makes the signal grow stronger March 1st, 2017

Smart multi-layered magnetic material acts as an electric switch: New study reveals characteristic of islands of magnetic metals between vacuum gaps, displaying tunnelling electric current March 1st, 2017

Bioinspired process makes materials light, robust, programmable at nano- to macro-scale: Ultralight web of silk nano fibers withstands load 4,000 times its weight February 28th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project