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Long interested in advancing the process of discovering new treatments for human diseases, the principals of QBI Life Sciences today announced the release of a second polymeric micelle product, PreserveX™-QML-B Polymeric Micelles. PreserveX™ Polymeric Micelles, useful in working with difficult to handle proteins average 21 nanometers in diameter. In the presence of native cell membrane fractions, PreserveX™ Polymeric Micelles self-assemble embedding pieces of cellular membranes in the complex creating multiple particles each providing an environment similar to that of the native membrane. Below is an illustration of this process.
The newly released product, PreserveX™-QML-B Polymeric Micelles contains a biotin label enabling the placement of the micelle/protein/lipid complex onto a solid support such as a protein microarray. Below is an illustration of complexes immobilized on a solid support.
PreserveX™ Polymeric Micelles reflect the combination of polymer chemistry technologies with protein chemistry technologies. Vladimir Trubetskoy, Ph.D., Director of Polymer Chemistry has headed up a team at QBI Life Sciences to develop polymer nano-particles that are useful in working with some of the most difficult to handle proteins. Focusing on membrane proteins (those proteins that reside on, near or embedded in cellular membranes), Dr. Trubetskoy and his team of scientists have come up with a set of very valuable drug discovery tools. In the area of human health, membrane proteins represent 70% of all known drug targets, the agents inside the human body upon which drugs evoke a therapeutic effect. To date, efforts to study these proteins and develop drugs targeting these proteins have been limited.
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