Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Synthesis of anti-cancer vaccines based on novel gold nanoparticles

Abstract:
Intensive program to develop anti-cancer vaccines based nanoscale particles

Midatech's CSIC team reports a new approach to the synthesis of anti-cancer vaccines based on novel gold nanoparticles

Oxford, UK | June 21, 2005

Scientists from the Laboratory of Glyconanotechnology at the CSIC in Seville, part of the UK-based Midatech Group, have initiated an intensive program to develop anti-cancer vaccines based upon creating immuno-stimulating nanoscale particles with an outer shell bearing specific carbohydrate and peptide antigens.

The team reports (1) (in Tetrahedron: Asymmetry) the successful synthesis of gold nanoparticles featuring covalently bonded, immunogenic oligosaccharides from the Ley determinant, which is associated with various carcinomas including colon, liver, prostate and ovarian.

The methodology ensures the preparation of functional, three-dimensional "glyco-stealth coronas" of immunogenic carbohydrate and peptide ligands on discreet, stable and water-soluble gold nanoparticles. To ensure maximum antigenicity, carbohydrate and peptide epitopes are linked covalently to the gold nanoparticle core by "spacers" of defined length. In this way a high surface density of the antigens is presented on the shell of the gold nanoparticles. Moreover these antigens are in their biologically correct conformation to stimulate antibody production.

The Lewis Y (LeY) determinant elicits antibodies against colon and liver carcinomas, and is over expressed in metastatic prostate cancer and in ovarian tumours. The LeY neoglycoconjugate synthesised consists of a tetrasaccharide covalently linked to a spacer (5 carbon chain) with a thiol end group. This is then covalently linked to the Au-S core.

The LeY-functionalised gold glyconanoparticles synthesized have been characterised by NMR spectroscopy and transmission electron microscopy (TEM). The particles are spherical in shape, with a mean diameter of 1.52 nm, from which it can be inferred that the cores contain 116-140 gold atoms.

Describing this important new development, Midatech Chief Operating Officer, Dr David Hill explains, "Of particular significance, is that the LeY-functionalised gold glyconanoparticles are very stable and water-soluble. In solution they are dispersed and discreet offering a highly immunogenic polyvalent system yet their microscopically minute dimensions of less than 2 nm means that the particles will be easily excreted by the kidneys.

The Midatech gold glyconanoparticles can be synthesized with specific carbohydrate and peptide moieties corresponding to well-characterised antigens from other cancer associated determinants, and we hope that this ingenious technology will lead to the creation of a range of novel, highly active anti-cancer vaccines in the future. Further studies are underway to evaluate the LeY-functionalised gold glyconanoparticles and Midatech will be announcing the results in due course."

####
Reference:
Synthesis of a LeY neoglycoconjugate and LeY-functionalized gold glyconanoparticles. JL de Paz et al. Tetrahedron: Asymmetry 16 (2005) 149-158

Notes to Editors:
The Carbohydrate Group in Seville established in 2001 that new well-defined, water soluble, three-dimensional carbohydrate polyvalent models or "nanocells" could be synthesised in the form of gold glyconanoparticles as a means to study biologically valuable carbohydrate interactions. These "nanocells" reproduce the clustering of cell-attached receptors and they can be considered as a useful tool for the rational analysis of carbohydrate interactions and as tools for the development of new techniques for screening diagnosis and therapy.

Midatech Ltd is the UK-based company formed in 2004 to develop the patent-protected technology platform generated by the Carbohydrate Group to focus on potential applications for gold glyconanoparticles in four key areas: imaging, drug delivery, siRNAs and DNA and vaccines - both therapeutic and preventative.

Contact:
Sarah Rogers
Healthcare Solutions
Hyde Lodge, Hyde Lane, Churt, FARNHAM, Surrey, GU10 2LP, UK
Tel: ++(0)1428 604444
sarah@healthcare-pr.co.uk

Copyright © Midatech Group

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Possible Futures

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Leti Will Demo World’s-first WVGA 10-µm Pitch GaN Microdisplays for Augmented Reality Video at Display Week in Los Angles: Invited Paper also Will Present Leti’s Success with New Augmented Reality Technology That Reduces Pixel Pitch to Less than 5 Microns May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Graphene-nanotube hybrid boosts lithium metal batteries: Rice University prototypes store 3 times the energy of lithium-ion batteries May 19th, 2017

Nanomedicine

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Oddball enzyme provides easy path to synthetic biomaterials May 17th, 2017

The brighter side of twisted polymers: Conjugated polymers designed with a twist produce tiny, brightly fluorescent particles with broad applications May 16th, 2017

Announcements

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Leti Will Demo World’s-first WVGA 10-µm Pitch GaN Microdisplays for Augmented Reality Video at Display Week in Los Angles: Invited Paper also Will Present Leti’s Success with New Augmented Reality Technology That Reduces Pixel Pitch to Less than 5 Microns May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Graphene-nanotube hybrid boosts lithium metal batteries: Rice University prototypes store 3 times the energy of lithium-ion batteries May 19th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project