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Abstract:
Zetasizer Nano is being used to optimize manufacturing conditions

Malvern’s Zetasizer Nano is used to optimize topical skin care formulation

June 07, 2005

Researchers at Particle Sciences, Inc. (Bethlehem, PA, USA), a company that develops and markets ingredients for personal care formulations, are using the Malvern Zetasizer Nano particle characterization system to investigate formulations of their recently developed, encapsulated form of retinol (Vitamin A). Retinol has been shown to have beneficial effects on photo-damaged skin, but is unstable in many formulation processes. This new encapsulated form is designed for the controlled release of the active following topical application.

The Zetasizer Nano is being used to optimize manufacturing conditions for this complex skin care formulation, a multi-component system. Examination of the effects of compositional changes on particle size and zeta potential has enabled better understanding and control of the parameters that determine suspension stability. The Zetasizer Nano is also being used to study the impact of surface chemistry on formulation issues such as the understanding of the surface and interfacial properties, as well as long term product stability.

The Malvern Zetasizer Nano series uses patented technologies to deliver particle size measurement in the range 0.6 to 6000 nm and measure the zeta potential of particles from 5 nm to 10 mm in diameter. It has the sensitivity required for the measurement of highly dilute proteins and polymers as well as the ability to analyze emulsions at high concentrations. All measurement routines are highly automated and an optional unit, the MPT-2 autotitrator is available to simplify the systematic study of size and zeta potential as a function of variables such as pH, conductivity or additive concentration.

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About Malvern Instruments Inc.:
Malvern Instruments is a leading supplier of analytical solutions for particle characterization and rheological applications. Advanced technologies are combined with robust mechanical designs and comprehensive software to provide systems that measure material characterization data (size distribution, particle shape, zeta potential, molecular weight) and bulk material properties. On-line, at-line and off-line solutions are provided to meet QA/QC, control and development applications across a diverse range of industries. An extensive support service facilitates the optimal design and exploitation of any given system.

For more information, please visit www.malvern.co.uk

About Particle Sciences, Inc:
Particle Sciences, Inc. is a privately held company, headquartered in Bethlehem, PA USA, which develops and markets advanced ingredients for personal care formulations. Emphasis is placed on the development of unique delivery systems to provide ease-of-formulation and stabilization to a wide range of cosmetic and pharmaceutical actives. Special emphasis is placed in the area of skin care delivery systems.

Particle Sciences, Inc. 3894 Courtney Street, Suite 180, Bethlehem, PA 18017

For more information, please visit www.particlesciences.com

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