Home > News > Targeting Nanoparticles to Leukemia Cells and T-Lymphocytes
June 1st, 2005
Targeting Nanoparticles to Leukemia Cells and T-Lymphocytes
Abstract:
Investigators in Germany have developed a method for creating antibody-labeled gelatin nanoparticles that can target specific cells and then dissolve upon uptake by those cells, raising the possibility that gelatin nanoparticles could serve as biodegradable drug delivery vehicles. Reporting its work in the journal Biomaterials, a research team led by Hagen von Briesen, Ph.D., of the Fraunhofer Institute for Biomedical Engineering in St. Ingbert, Germany, showed that crosslinked gelatin nanoparticles could be readily labeled with an antibody that binds to the cell-surface protein CD3. This protein is found on the surface of certain types of leukemic T-lymphocytes.
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NCI
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Fraunhofer Institute for Biomedical Engineering
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