Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Undercover Tactics

Abstract:
Soft shell, hard core: nanotubes made of cyclic peptides with a synthetic polymer coating

Undercover Tactics

May 11, 2005

Ever since the discovery of carbon nanotubes in the early 1990s, scientists and engineers have been fascinated by the possibilities for these little tubes made of organic materials in the fields of microelectronics, substance separation, and biomedicine. Freiburg researchers have now produced novel nanotube hybrids from peptides and polymers: nanotubes made of cyclic peptides are coated with a soft polymeric plastic shell.

Cyclic peptides are small molecules whose amino acid chains form a ring. The amino and acid groups, as well as the hydrogen atom can be arranged in two ways around the first carbon atom (known as the "alpha C-atom") of an amino acid. This allows the molecule to have either a "left" or a "right" configuration. While mother nature uses almost exclusively "left" amino acids in proteins, the team headed by Markus Biesalski at IMTEK (Institute of Microsystem Technology) are building up cyclic peptides according to the "one right, one left" scheme, a technique that has been pioneered by Reza Ghadiri (Scripps Institute, San Diego). Such peptide rings organize themselves into a tiny tubular structure. All of the peptide side chains stick out of the tube, leaving a cavity inside. The dimensions of the tube are determined by the number of amino acid building blocks in the peptide rings.

The special trick in this case is that some of the side chains selected are of a type that can act as starting points for the growth of artificial polymer chains. They can thus form a strongly bound shell of soft plastic around the relatively hard peptide nanotube. In their initial experiments, the researchers used N-isopropylacrylamide as the molecular building block for the polymer. Images obtained with an atomic force microscope revealed solvent-free ("dry") individual rod-shaped objects about 80 nm long and 12 nm high.

The plastic used is not toxic and has interesting physical properties. In a certain temperature range, the polymer matrix collapses. This property could be useful in biomedicine, for drug transport, as an example: an enclosed drug could be released at a specific target in the body. Numerous other applications can also be imagined for these hybrid materials.

This new principle is very versatile: "By varying the type of polymer, the density of attachment points, and the chain length, we are able to produce hybrid nanotubes with tunable properties," says Biesalski. "We are now carrying out systematic studies to this end in our laboratory."

To view the abstract or full article ("Peptide-Polymer Hybrid Nanotubes"), visit www.interscience.wiley.com

####

Contact:
Dr. M. Biesalski Institut für Mikrosystemtechnik (IMTEK)
Albert-Ludwigs-Universität
Freiburg
Georges-Köhler-Allee 103
D-79110 Freiburg
Germany
Tel.: (+49) 761-203-7162
Fax: (+49) 761-203-7163
biesalsk@imtek.de

Copyright © Angewandte Chemie

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Possible Futures

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanocomposites Market Growth, Industry Outlook To 2020 by Grand View Research, Inc. March 21st, 2015

Nanotechnology Drug Delivery Market in the US 2012-2016 : Latest Report Available by Radiant Insights, Inc March 16th, 2015

Nanotubes/Buckyballs

From tobacco to cyberwood March 31st, 2015

Wrapping carbon nanotubes in polymers enhances their performance: Scientists at Japan's Kyushu University say polymer-wrapped carbon nanotubes hold much promise in biotechnology and energy applications March 30th, 2015

Carbon nanotube fibers make superior links to brain: Rice University invention provides two-way communication with neurons March 25th, 2015

Iranian Scientists Eliminate Expensive Materials from Diabetes Diagnosis Sensors March 25th, 2015

Nanomedicine

Nanion Technologies Appoints James Costantin as Director of Customer Relations: Nanion is pleased to announce the appointment of Dr. James Costantin as Director of Customer Relations at Nanion Technologies Inc. March 31st, 2015

Nanomedicine shines light on combined force of nanomedicine and regenerative medicine March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

Announcements

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Super sensitive measurement of magnetic fields March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE