Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > 'Nano-bumps' Could Help Repair Clogged Blood Vessels

Abstract:
Researchers have shown that bone and cartilage cells in petri dishes attach better to materials that possess smaller surface bumps than are found on conventional materials

'Nano-bumps' Could Help Repair Clogged Blood Vessels

West Lafayette, IN | April 19, 2005

Biomedical engineers at Purdue University have shown that "vascular stents" used to repair arteries might perform better if their surfaces contained "nano-bumps" that mimic tiny features found in living tissues.

The researchers already have shown in a series of experiments that bone and cartilage cells in petri dishes attach better to materials that possess smaller surface bumps than are found on conventional materials used to make artificial joints. The smaller features also stimulate the growth of more new bone tissue, which is critical for the proper attachment of artificial joints once they are implanted.

Now the biomedical engineers have seen the same kind of increased attachment for endothelial and vascular smooth muscle cells lining the insides of arteries, said Thomas Webster, an associate professor of biomedical engineering at Purdue.

The stents are small metal scaffolds that are inserted inside arteries to prop them open during or after surgery to remove dangerous plaque deposits from the vessels. The stents, which are made of titanium and other metals, enable the arteries to grow new tissue after vessel-clogging plaque deposits have been removed. A major problem, however, is that the body often perceives the metal devices as foreign invaders, hindering endothelial cells from attaching to the scaffolding and prompting the creation of scar tissue, which can build up inside blood vessels and interfere with blood flow.

"If a stent doesn't attach firmly it can become loose, and parts of it will actually break off and go down the bloodstream," Webster said. "Essentially, what we've been trying to do is find new materials that cause the endothelial cells to attach better to these stents without creating as much dangerous scar tissue."

The researchers tested discs of titanium containing surface bumps about as wide as 100 nanometers - or billionths of a meter. The metals used to make conventional stents have features about 10 times larger or none at all. The nanometer-scale bumps mimic surface features of proteins and natural tissues, prompting cells to stick better, Webster said.

"Ideally, you want endothelial cells to quickly attach to stents and form a coating only one cell layer thick, which we call a monolayer," Webster said. "Otherwise, if the metal is not entirely coated, blood cells passing through the repaired artery come into contact with the metal and recognize it as foreign."

Findings will be presented on April 28 during the Society for Biomaterials' 2005 Annual Meeting and Exposition in Memphis, Tenn. The work was conducted by graduate student Saba Choundhary, Webster and Karen Haberstroh, an assistant professor of biomedical engineering.

The researchers placed titanium discs possessing the nano-features into petri plates containing a suspension of endothelial cells. After one hour, the discs were washed and a microscope was used to count how many of the dyed cells adhered to the material. The researchers found that nearly three times as many cells stuck to the discs containing the nano-bumps, as compared to ordinary titanium.

"After one hour, we get three times more endothelial cell coverage of the metal if it has nano- features," Webster said.

Numerous surgeries involving stents are performed annually worldwide, with sales of "vascular biomaterials" adding up to more than $1 billion each year.

The research has been funded by the National Science Foundation. Webster's lab is affiliated with the Birck Nanotechnology Center and the Bindley Bioscience Center, which are in Purdue's Discovery Park, the university's hub for high-tech research.

Further research is planned that will replace the titanium disks with tube-shaped pieces of the nano-featured metal, which will resemble the actual shape of real stents.

####


Writer:
Emil Venere
(765) 494-4709
venere@purdue.edu

Sources:
Thomas Webster
(765) 496-7516
twebster@purdue.edu

Karen Haberstroh
(765) 496-7517
khaberst@purdue.edu

Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Birck Nanotechnology Center

Related News Press

Possible Futures

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Leti Will Demo World’s-first WVGA 10-µm Pitch GaN Microdisplays for Augmented Reality Video at Display Week in Los Angles: Invited Paper also Will Present Leti’s Success with New Augmented Reality Technology That Reduces Pixel Pitch to Less than 5 Microns May 22nd, 2017

Nanomedicine

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Oddball enzyme provides easy path to synthetic biomaterials May 17th, 2017

The brighter side of twisted polymers: Conjugated polymers designed with a twist produce tiny, brightly fluorescent particles with broad applications May 16th, 2017

Announcements

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

Leti to Demo 1st Wireless UNB Transceiver for ‘Massive Internet of Things’ at RFIC 2017 and IMS 2017: Leti Will also Present Three Papers & Two Workshops on 5G Communications IC Design, from RF to mm-Wave, During IMS 2017 and RFIC 2017 in Hawaii May 24th, 2017

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project