As downsized silicon devices approach nanometer dimensions, single-molecule memory cells challenge conventional wisdom. Today every micron-size capacitor in a DRAM cell is fastidiously refreshed every millisecond just to guarantee that bleeding electrons don't float the voltage past the boundary between zero and one. If that's the case, how often will individual molecules and single-electron devices need refreshing? Will nanoscale devices retain the same properties of their micron-size brethren? Will such organic molecules even be able to survive the high temperatures of semiconductor fabrication?