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October 31st, 2003
Novel Gene Therapy Effectively Reduces Asthma Symptoms in Mice
A novel nasal spray containing minuscule particles that deliver therapeutic protein-producing genes effectively reduces allergen-induced airway inflammation and hyper-reactivity, the hallmark symptoms of asthma. "By treating asthmatic mice with this gene therapy, we have allowed their lungs to produce the protein, interferon gamma, that is needed to reduce asthmatic symptoms," said Shyam S. Mohapatra, PhD, principal investigator. Mohapatra and his team selected chitosan nanoparticles as a delivery method for interferon gamma gene.
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