Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Radiation-guided nanoparticles zero in on metastatic cancer

This is a schematic illustration of selectins' role in inflammation (A) and cancer progression (B). This mechanism can be used for selectin-based targeted therapy (C). This material relates to a paper that appeared in the June 29, 2016 issue of Science Translational Medicine, published by AAAS. The paper, by Y. Shamay at Memorial Sloan Kettering Cancer Center	in	New York, NY, and colleagues was titled, "P-selectin is a nanotherapeutic delivery target in the tumor microenvironment."
CREDIT: Kedmi et al., Science Translational Medicine (2016)
This is a schematic illustration of selectins' role in inflammation (A) and cancer progression (B). This mechanism can be used for selectin-based targeted therapy (C). This material relates to a paper that appeared in the June 29, 2016 issue of Science Translational Medicine, published by AAAS. The paper, by Y. Shamay at Memorial Sloan Kettering Cancer Center in New York, NY, and colleagues was titled, "P-selectin is a nanotherapeutic delivery target in the tumor microenvironment."

CREDIT: Kedmi et al., Science Translational Medicine (2016)

Abstract:
Zap a tumor with radiation to trigger expression of a molecule, then attack that molecule with a drug-loaded nanoparticle. That's the approach researchers working in mice have taken in a new study that aims to make delivery of chemotherapy to metastatic tumors more effective.

Radiation-guided nanoparticles zero in on metastatic cancer

Washington, DC | Posted on July 1st, 2016

The researchers say that the radiation-guided nanoparticles may offer a new approach for penetrating the vascular barrier that often thwarts current nanomedicines from reaching metastatic tumors. To spread to distant organs, cancer cells in the bloodstream latch onto adhesion molecules known as P-selectins in the blood vessel walls. Yosi Shamay and colleagues further found that unlike normal tissues, many human cancers--including lung, ovarian, breast, and liver--overexpress P-selectin on tumor cells and in surrounding blood vessels. To exploit this molecule as a therapeutic target, the researchers designed nanoparticle drug carriers composed of fucoidan, a seaweed-derived compound that naturally binds to P-selectin. In a mouse model of lung cancer and metastatic melanoma and breast tumors, all of which express P-selectin, the nanoparticles selectively delivered chemotherapy drugs to the tumors, improving tumor reduction and overall survival better than did the free form of the drugs or drug-loaded nanoparticles not made of fucoidan. For tumors that do not normally express P-selectin, Shamay et al. used radiation, which is known to boost P-selectin expression in tissues, to guide the nanoparticles to the tumor site. When combined with radiation, the nanotherapy effectively shrunk lung tumors lacking P-selectin in mice. In a related Focus, Ranit Kedmi and Dan Peer discuss the promises and challenges of moving the nanotherapy to the clinic. Radiation-guided nanoparticles may offer a new tool for delivering drugs to almost any tumor, they note, but further development would need to address the double-edged sword of radiation's potential to trigger P-selectin expression that might unintentionally promote cancer spread.

####

For more information, please click here

Contacts:
Science Press Package Team

202-326-6440

Copyright © American Association for the Advancement of Science (AAAS)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

RELATED JOURNAL ARTICLE:

Related News Press

News and information

Researchers develop artificial building blocks of life March 8th, 2024

How surface roughness influences the adhesion of soft materials: Research team discovers universal mechanism that leads to adhesion hysteresis in soft materials March 8th, 2024

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

Cancer

University of Toronto researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects: Study findings make significant contribution to generating tissue-specific ionizable lipids and prompts rethinking of mRNA vaccine design princi December 8th, 2023

Super-efficient laser light-induced detection of cancer cell-derived nanoparticles: Skipping ultracentrifugation, detection time reduced from hours to minutes! October 6th, 2023

The medicine of the future could be artificial life forms October 6th, 2023

Chung-Ang University researchers develop novel DNA biosensor for early diagnosis of cervical cancer: The electrochemical sensor, made of a graphitic nano-onion/molybdenum disulfide nanosheet composite, detects human papillomavirus (HPV)-16 and HPV-18, with high specificity September 8th, 2023

Possible Futures

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Nanomedicine

High-tech 'paint' could spare patients repeated surgeries March 8th, 2024

Researchers develop artificial building blocks of life March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

Discoveries

What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024

Researchers’ approach may protect quantum computers from attacks March 8th, 2024

High-tech 'paint' could spare patients repeated surgeries March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Announcements

What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Researchers develop artificial building blocks of life March 8th, 2024

How surface roughness influences the adhesion of soft materials: Research team discovers universal mechanism that leads to adhesion hysteresis in soft materials March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Nanobiotechnology

High-tech 'paint' could spare patients repeated surgeries March 8th, 2024

Researchers develop artificial building blocks of life March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project