Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Radboud University Nijmegen applies nanoparticle tracking analysis from NanoSight to study molecular machines.

Dr Daniela Wilson with her NanoSight systems at the Radboud University in the Netherlands.
Dr Daniela Wilson with her NanoSight systems at the Radboud University in the Netherlands.

Abstract:
NanoSight, leading manufacturers of unique nanoparticle characterization technology, report on how the Radboud University Nijmegen is applying nanoparticle tracking analysis for the characterization of self-assembled nanomotors.

Radboud University Nijmegen applies nanoparticle tracking analysis from NanoSight to study molecular machines.

Salisbury, UK | Posted on March 27th, 2012

The oldest city in the Netherlands has provided the home for the latest exciting development in nanotechnology. Jet-engined nano-size rockets may provide a solution for delivering drug packages in the human body. This is not science fiction; it is science fact! Nature Chemistry has published a paper outlining the latest work of Daniela A. Wilson, Roeland J. M. Nolte and Jan C. M. van Hest from the Institute for Molecules and Materials (IMM), Radboud University, Nijmegen.

Dr Daniela A. Wilson explains the work of the group. "Making a nanomotor has been a dream of many researchers in nanotechnology. From molecular machines to micron size self-propelling rods, our team has used a combination of bottom-up or top-down approaches taking years off synthetic work. We applied self-assembly as a tool just like the pieces of a puzzle. The only difference is that we allowed the building blocks make itself to form 350 nm sized motors. The next step was to prove the concept. Having constructed these sub-micron sized nanomotors, we could not use conventional microscopies to visualize them. For 350 nm size particles, we required a special technique and this is how we have come to be users of the NanoSight technique of nanoparticle tracking analysis, NTA. This tracks the motors one by one (in effect, particle-by-particle). We could even analyze their movement after the addition of their fuel (hydrogen peroxide)."

Dr Wilson continued: "Knowing the particle size was very important to establish the size distribution of our self-assembled nanomotors as well the entrapment of the catalytic particles inside the bowl shape structures. However, even more important for us was the ability to track the movement of the motors in the presence of the fuel. This provided the definitive proof of directed motion resulting from the fast discharge of oxygen."

Prior to using NTA, the IMM group used dynamic light scattering (DLS). While quite powerful to measure size, it did not provide the ability to track individual particles that was essential for this research. Furthermore, it was vital to be able to analyze particle movement in real time. NanoSight uses tracking and scattering information to provide the size of the particles as well as giving information about the purity of its components. Different refractive indexes materials within the same colloidal distribution will give different scattering and therefore the group is able to use that information to assess the purity and distribution of complex mixtures.

To find out about the company and to learn more about particle characterization using NanoSight's unique nanoparticle tracking analysis solutions, visit www.nanosight.com and register to receive the next issue of NanoTrail, the company's electronic newsletter.

####

About NanoSight
NanoSight delivers the world's most versatile and proven multi-parameter nanoparticle analysis in a single instrument.

NanoSight's "Nanoparticle Tracking Analysis" (NTA) detects and visualizes populations of nanoparticles in liquids down to 10nm, dependent on material, and measures the size of each particle from direct observations of diffusion. Additionally, NanoSight measures concentration and a fluorescence mode differentiates suitably-labelled particles within complex background suspensions. Zeta potential measurements assess the surface charge on particles. NTA's particle-by-particle methodology goes beyond traditional light scattering and other ensemble techniques in providing high-resolution particle size distributions and validates data with information-rich video files of the particles moving under Brownian motion.

NanoSight's simultaneous multiparameter characterization matches the demands of complex biological systems, hence its wide application in development of drug delivery systems, of viral vaccines, and in nanotoxicology. This real-time data gives insight into the kinetics of protein aggregation and other time-dependent phenomena in a qualitative and quantitative manner. NanoSight has a growing role in biodiagnostics, being proven in detection and speciation of nanovesicles (exosomes) and microvesicles.

NanoSight has installed more than 400 systems worldwide with users including BASF, GlaxoSmithKline, Merck, Novartis, Pfizer, Proctor and Gamble, Roche and Unilever together with the most eminent universities and research institutes. NanoSight's technology is validated by 300+ third party papers citing NanoSight results, consolidating NanoSight's leadership position in nanoparticle characterization.

For more information, please click here

Contacts:
NanoSight Limited
Minton Park
London Road
Amesbury SP4 7RT UK
T +44(0)1980 676060
F +44(0)1980 624703


Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA UK
T +44(0)1799 521881
M +44(0)7843 012997
www.talking-science.com

Copyright © NanoSight

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

New flexible material can make any window 'smart' August 23rd, 2016

University of Puerto Rico and NASA back in the news XEI reports August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

Molecular Machines

Legions of nanorobots target cancerous tumors with precision: Administering anti-cancer drugs redefined August 16th, 2016

New remote-controlled microrobots for medical operations July 23rd, 2016

Pushing a single-molecule switch: An international team of researchers from Donostia International Physics Center, Fritz-Haber Institute of the Max Planck Society, University of Liverpool, and the Polish Academy of Sciences has shown a new way to operate a single-molecule switch July 19th, 2016

Researchers harness DNA as the engine of super-efficient nanomachine: New platform detects traces of everything from bacteria to viruses, cocaine and metals July 10th, 2016

Self Assembly

Smarter self-assembly opens new pathways for nanotechnology: Brookhaven Lab scientists discover a way to create billionth-of-a-meter structures that snap together in complex patterns with unprecedented efficiency August 9th, 2016

Magnetic atoms arranged in neat rows: FAU physicists enable one-dimensional atom chains to grow August 5th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

WSU researchers develop shape-changing 'smart' material: Heat, light stimulate self-assembly July 4th, 2016

Nanomedicine

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Curbing the life-long effects of traumatic brain injury August 19th, 2016

Lab team spins ginger into nanoparticles to heal inflammatory bowel disease August 19th, 2016

Discoveries

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

New flexible material can make any window 'smart' August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

Researchers reduce expensive noble metals for fuel cell reactions August 22nd, 2016

Announcements

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

New flexible material can make any window 'smart' August 23rd, 2016

University of Puerto Rico and NASA back in the news XEI reports August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic